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pentobarbital will reduce the extent or result of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.pentobarbital will minimize the level or result of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a delicate CYP3A4 substrate. Coadm